David E. Sandberg, Ph.D.
Professor, Department of Pediatrics and Communicable Diseases
Dr. Sandberg is a pediatric psychologist and clinical researcher. As a clinician, he delivers psychoeducational and behavioral health services to persons with endocrine disorders and their families, in particular, conditions affecting linear growth or disorders of sex development (DSD). DSD are congenital conditions in which development of chromosomal, gonadal, or anatomic sex is atypical.
Dr. Sandberg's research program is closely linked to his clinical service and includes the study of the psychosocial aspects of short stature and the effects of growth hormone on quality of life outcomes. His research group also examines the psychosocial adaptation of persons born with DSD, and their families. He shares the role of principal investigator in a registry-based translational research network for DSD designed to extend discoveries in the genetics and pathophysiology of these conditions (DSD-Translational Research Network, NIH R01 HD068138). The network will standardize procedures in diagnosis and clinical decision-making and develop tools necessary to translate diagnostic and treatment protocols into clinical best practices.
Dr. Sandberg's focus on the psychosocial aspects of DSD is also reflected in the development of a psychoeducational treatment manual for clinicians caring for newborns with congenital adrenal hyperplasia (CAH) identified by newborn screen (subcontract to the National Newborn Screening and Genetics Resource Center). This preliminary work led to a grant (PI: Sandberg) to create a web-based platform for both providers and parents of newborns/young children with CAH (NIH R41 HD057714).
Dr. Sandberg has also been awarded a grant (PI: Sandberg, NIH R01 HD053637), to design health-related quality of life (HRQoL) measures that focus on issues specific to, and shared by young children with DSD and their families, which are not otherwise covered by generic HRQoL measures .
Genital surgery in young children with DSD is among the most controversial topics in the management of these conditions. To ensure that decisions made by parents in consultation with their child's providers are evidence-based, balanced, and fully informed, Dr. Sandberg was recently awarded a contract from the Patient Centered Outcomes Research Institute (PCORI 1360). This multisite project that involves the input of provider specialists from multiple disciplines, representatives of DSD patient support/advocacy organizations and parents of affected children, will deliver a web-based decision support tool.
Post-Doctoral Research Scientist in Psychiatry, College of Physicians & Surgeons of Columbia University, New York, 1988
Postdoctoral Fellow, University of Miami Medical School, Miami, 1983
Ph.D., Psychology (Concentrations: Clinical and Behavioral Endocrinology), Concordia University, Montreal, 1982
M.A., Experimental Psychology, Bar-Ilan University, Israel, 1977
B.A., Psychology, Bar-Ilan University, Israel, 1975
Refereed Journals, Letters to the Editor, Editorial Commentaries, Invited Articles/Commentaries.
(* denotes psychology/medical student, resident, or fellow supervised by Sandberg)
(A) Refereed Journals
Short Stature: Is it a psychosocial problem and does changing height matter?
Pediatric Clinics of North America, in press.
Unbiased Identification of Patients with Disorders of Sex Development
PLoS ONE, 9(9), e108702. doi: 10.1371/journal.pone.0108702.
DSDs: genetics, underlying pathologies and psychosexual differentiation
Nature Reviews Endocrinology 2014, advance online publication 5 August 2014; doi:10.1038/nrendo.2014.130.
“It was an overwhelming thing”: Parents’ needs after infant diagnosis with CAH.
Journal of Pediatric Nursing 2014; e-pub ahead of print, 15 January 2014.
Management of children with DSD - new care standards explained.
Psychology and Sexuality 2014; 5(1),5-14.
(B) Letters to the Editor
Comments on "Short Adult Stature and Overweight Are Associated with Poor Intellectual Performance in Subjects Born Preterm" by Lundgren et al., Hormone Research.
Paediatrics 2011;75:138–145 Hormone Research in Pædiatrics 2011;75:146-147.
Gender identity stability and diagnosis in 5α-reductase deficiency.
Journal of Clinical Endocrinology and Metabolism. 2011; Published September 14.
From principles to process in disorders of sex development (DSD) care.
Horm Res Pædiatr. 2010;74(6):419–20.
Height and social adjustment: In reply.
Pediatrics. 2005;115:516- 517.
Sex determination, differentiation, and identity.
New England Journal of Medicine. 2004;350 (21):2204.
(C) Editorial Commentaries for Growth, Genetics and Hormones
Treatment guidelines for children with disorders of sex development.
Growth, Genetics and Hormones. 2009;25(1):39-41.
Prevention of pediatric obesity: Meta-analysis of behavioral interventions.
Growth, Genetics and Hormones. 2009;25(1):21-22.
Pediatric obesity: Meta-analysis of non-surgical interventions.
Growth, Genetics and Hormones. 2009;25(1):19-21.
Disorders of Sex Development: Nomenclature. Letter to the Editor.
Growth, Genetics and Hormones. 2009;25(1):9-10.
Genital function and sensitivity following feminizing surgery.
Growth, Genetics and Hormones. 2008;24 (2):52-53.
(D) Invited Articles/Commentaries
It’s not how short you are, but how you got there that counts.
Horm Res Pædiatr. 2011;75:146- 147.
Interpreting research results: the dangers of scientific jargon.
Cares Foundation Newsletter. 2006;5:8-9.
Growth hormone treatment for short stature: Inferences from FDA decisions and clinical practice.
Atrium. The Report of the Northwestern Medical Humanities and Bioethics Program. 2006;3:15-17. Available at: http://www.ama-assn.org/ama1/pub/upload/mm/384/cc2-short15623.pdf
Health-related quality of life as a primary endpoint for growth hormone therapy.
Hormone Research. 2006;65:250-252.
Treating short stature with growth hormones.
Virtual Mentor. Ethics Journal of the American Medical Association. 2005;11. Available at: http://www.ama-assn.org/ama1/pub/upload/mm/384/cc2- short15623.pdf
Disorders of Sex Development: A Survey of Clinical Practice
Disorders of Sex Development: Platform for Basic and Translational Research
Family Education for Confirmed Newborn Screen
Health-Related Quality of Life: A Pediatric Clinical and Research Tool