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David E. Sandberg, Ph.D. Professor, Department of Pediatrics and Communicable Diseases
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Biography
Dr. Sandberg is a pediatric psychologist and clinical researcher. As a clinician, he delivers psychoeducational and behavioral health services to persons with endocrine disorders and their families, in particular, conditions affecting linear growth or disorders of sex development (DSD). DSD are congenital conditions in which development of chromosomal, gonadal, or anatomic sex is atypical.
Dr. Sandberg's research program is closely linked to his clinical service and includes the study of the psychosocial aspects of short stature and the effects of growth hormone on quality of life outcomes. His research group also examines the psychosocial adaptation of persons born with DSD, and their families. He shares the role of principal investigator in a registry-based translational research network for DSD designed to extend discoveries in the genetics and pathophysiology of these conditions (DSD-Translational Research Network, NIH R01 HD068138). The network will standardize procedures in diagnosis and clinical decision-making and develop tools necessary to translate diagnostic and treatment protocols into clinical best practices.
Dr. Sandberg's focus on the psychosocial aspects of DSD is also reflected in the development of a psychoeducational treatment manual for clinicians caring for newborns with congenital adrenal hyperplasia (CAH) identified by newborn screen (subcontract to the National Newborn Screening and Genetics Resource Center). This preliminary work led to a grant (PI: Sandberg) to create a web-based platform for both providers and parents of newborns/young children with CAH (NIH R41 HD057714).
Dr. Sandberg has also been awarded a grant (PI: Sandberg, NIH R01 HD053637), to design health-related quality of life (HRQoL) measures that focus on issues specific to, and shared by young children with DSD and their families, which are not otherwise covered by generic HRQoL measures .
Genital surgery in young children with DSD is among the most controversial topics in the management of these conditions. To ensure that decisions made by parents in consultation with their child's providers are evidence-based, balanced, and fully informed, Dr. Sandberg was recently awarded a contract from the Patient Centered Outcomes Research Institute (PCORI 1360). This multisite project that involves the input of provider specialists from multiple disciplines, representatives of DSD patient support/advocacy organizations and parents of affected children, will deliver a web-based decision support tool.
Education
Post-Doctoral Research Scientist in Psychiatry, College of Physicians & Surgeons of Columbia University, New York, 1988
Postdoctoral Fellow, University of Miami Medical School, Miami, 1983
Ph.D., Psychology (Concentrations: Clinical and Behavioral Endocrinology), Concordia University, Montreal, 1982
M.A., Experimental Psychology, Bar-Ilan University, Israel, 1977
B.A., Psychology, Bar-Ilan University, Israel, 1975
Peer-Reviewed Publications
Refereed Journals, Letters to the Editor, Editorial Commentaries, Invited Articles/Commentaries.
(* denotes psychology/medical student, resident, or fellow supervised by Sandberg)
(A) Refereed Journals
Management of children with DSD - new care standards explained.
Psychology and Sexuality. Published online: 02 Sep 2013.
Warning about warnings: weighing risk and benefit when information is in a state of flux.
Hormone Research in Pædiatrics 2013; 79(1):4-8.
Targeted massively parallel sequencing provides comprehensive genetic diagnosis for patients with disorders of sex development.
Clinical Genetics 2013 Clinical Genetics, 83(1), 35-43.
Challenges of DSD: Diverse perceptions across stakeholders.
Hormone Research in Paediatrics 2012;78(1):40-6.
Management of disorders of sex development: Editorial commentary.
Pediatric Clinics of North America 2012;59(4):871-880.
Psychological aspects of the treatment of patients with disorders of sex development.
Seminars in Reproductive Medicine 2012;30(5):443-452.
Growth hormone treatment for short stature: A review of psychosocial assumptions and empirical evidence.
Pediatric Endocrinology Reviews 2011;9(2):579-588.
Children with disorders of sex development: A qualitative study of early parental experience.
International Journal of Pediatric Endocrinology 2011. 2011:10.
Psychosocial aspects of short stature and its management: good deeds require good science.
Horm Res Pædiatr. 2011;76 Suppl 3:37-9.
Short stature: psychosocial interventions.
Horm Res Pædiatr. 2011;76 Suppl 3:29-32.
Guidelines for the Development of Comprehensive Care Centers for Congenital Adrenal Hyperplasia: Guidance from the CARES Foundation Initiative.
Int J Pediatr Endocrinol. 2010;2010:275213.
Should disorders of sex development be an exclusion criterion for gender identity disorder in DSM 5?
International Journal of Transgenderism 2010;12(2):94- 99.
Congenital adrenal hyperplasia: review of studies employing psychological endpoints.
Int J Pediatr Endocrinol. 2010;2010:191520.
Short Stature in a Population-Based Cohort: Social, Emotional, and Behavioral Functioning.
Pediatrics 2009;124 (3):903-910.
Health-related quality of life of children and adolescents with growth hormone deficiency or idiopathic short stature – Part 2: Available results and future directions.
Hormone Research, 2009;72:74– 81.
Assessment of health-related quality of life and patient satisfaction in children and adolescents with growth hormone deficiency or idiopathic short stature – Part 1: A critical evaluation of available tools.
Hormone Research, 2009;72:65–73.
Consensus statement on the diagnosis and treatment of children with idiopathic short stature: A summary of the Growth Hormone Research Society, the Lawson Wilkins Pediatric Endocrine Society and the European Society for Paediatric Endocrinology Workshop.
Journal of Clinical Endocrinology & Metabolism. 2008;93:4210-4217.
Growth trajectory during early life and risk of adult schizophrenia.
British Journal of Psychiatry. 2007;191:512-520.
Consensus statement on management of intersex disorders.
Archives of Diseases in Childhood. 2006;91:554-563. Also published in Journal of Pædiatric Urology; Clinical Pædiatric Endocrinology; Pediatrics (e-publication, printed summary).
Growth hormone treatment of short stature: status of the quality of life rationale. A mini-review.
Hormone Research. 2005;63:275-283.
Conference proceedings: Research on intersex. Summary of a planning workshop.
Endocrinologist. 2004;14:59-69.
Psychological adaptation in children with idiopathic short stature treated with growth hormone or placebo. J
ournal of Clinical Endocrinology and Metabolism. 2004;89:4873-4878.
The psychological burden of short stature. Evidence against.
European Journal of Endocrinology. 2004;151:S29- S33.
Male pseudohermaphroditism: long-term quality of life outcome in five 46,XY individuals reared female.
Journal of Pediatric Endocrinology and Metabolism. 2004;17 (6):809-823.
Height and social adjustment: Are extremes a cause for concern and action?
Pediatrics. 2004;114:744–750.
A newborn infant with a disorder of sexual differentiation.
Journal of Developmental & Behavioral Pediatrics. 2003;24:115-119.
Hormonally active agents in the environment and children’s behavior: assessing effects on children’s gender-dimorphic outcomes.
Epidemiology. 2003;14:148-155.
The psychosocial consequences of short stature: A review of the evidence. Baillière’s Best Practice & Research.
Clinical Endocrinology and Metabolism. 2002;16(3):449-463.
Identification of sport fish consumption patterns in families of recreational anglers through factor analysis.
Environmental Research. 2002;89:19-28.
Psychosocial adaptation of middle childhood boys with hypospadias after genital surgery.
Journal of Pediatric Psychology. 2001;26:465-475.
The quality-of-life benefits of growth hormone-increased final height: what do we know?
The Endocrinologist. 2001;11(4)(Suppl 1):8S-14S.
The association of sexual behavior with externalizing behaviors in a community sample of prepubertal children.
Journal of Psychology and Human Sexuality. 2000;12:61-79.
Perceived versus measured height: Which is the stronger predictor of psychosocial functioning?
Hormone Research. 2000;53:129-138.
Growth hormone therapy in childhood-onset growth hormone deficiency: adult anthropometric and psychological outcomes.
Endocrine. 2000;12:173-182.
Should short children who are not deficient in growth hormone be treated?
Western Journal of Medicine. 2000;172:186-189.
Perception of family functioning and depressive symptomatology in individuals with anorexia nervosa or bulimia nervosa.
Comprehensive Psychiatry. 1999;40:434-441.
Peer relations: the bread and thread of life.
Acta Paediatrica. 1999;88:108- 109.
Current dosing of growth hormone in children with growth hormone deficiency: How physiologic?
Pediatrics. 1998;102 (Suppl):527-530.
Academic adjustment among children and adolescents receiving growth hormone therapy.
Children’s Health Care. 1998;27:265- 282.
Quality of life (QOL) among formerly treated child- onset growth hormone-deficient (GHD) adults: a comparison with unaffected siblings.
Journal of Clinical Endocrinology & Metabolism. 1998;83:1134- 1142.
Outcome following lower L-thyroxine dose for treatment of congenital hypothyroidism.
Clinical Pediatrics. 1995;October:514-520.
Gender development in boys born with hypospadias.
Psychoneuroendocrinology. 1995;20:693-709.
Endocrine disorders in childhood: a selective review of educational sequelae.
School Psychology Review. 1995;24:144-168.
Questionnaire scales for the assessment of atypical gender development in girls and boys.
Journal of Psychology and Human Sexuality. 1994;6:19- 39.
Seasonal patterns in eating disorder subgroups.
Comprehensive Psychiatry. 1994;35:450-456.
Short stature: a psychosocial burden requiring growth hormone therapy?
Pediatrics. 1994;94:832- 840.
Gender-related assessment of childhood play.
Journal of Abnormal Child Psychology. 1994;22:643-660.
Variability in middle childhood play behavior: effects of gender, age and family background.
Archives of Sexual Behavior. 1994;23:645-662.
Feminine gender-role behavior and academic achievement: their relation in a community sample of middle childhood boys.
Sex Roles. 1993; 29:125-140.
The prevalence of gender-atypical behavior in elementary school children.
Journal of the American Academy of Child and Adolescent Psychiatry. 1993;32:306- 314.
Recent developments in the study of the psychosocial aspects of short stature.
Growth, Genetics & Hormones. 1992;8:5-6.
Depressive and anxiety disorders in anorexia nervosa and bulimia nervosa.
The International Journal of Eating Disorders. 1992;12:21-29.
Gender differences in children's and adolescents' career aspirations. A follow-up study.
Journal of Adolescent Research. 1991;6:371-386.
Nonorganic nutritional dwarfing: Is it a consequence of disturbed psychosocial functioning?
Pediatrics. 1991;88:926-933.
The child behavior checklist nonclinical standardization samples: should they be utilized as norms?
Journal of the American Academy of Child and Adolescent Psychiatry. 1990;30:124- 134.
Effects of prenatal methadone exposure on sex-dimorphic behavior in early school-age children.
Psychoneuroendocrinology. 1990;15:77-82.
Boys with hypospadias: A survey of behavioral difficulties.
Journal of Pediatric Psychology. 1989;14: 491-514.
Methodological issues in assessing AIDS prevention programs.
Journal of Adolescent Research. 1988;3:413-418.
The influence of individual and family characteristics upon career aspirations of girls during childhood and adolescence.
Sex Roles. 1987;16:649-668.
Play interactions and interviews of depressed and conduct disorder children and their mothers.
Child Psychiatry and Human Development. 1987;17:213-234.
Effects of ultrasound feedback on pregnancy anxiety, fetal activity and neonatal outcome.
Obstetrics and Gynecology. 1985;66:525-528.
Pregnancy problems, postpartum depression and early mother-infant interactions.
Developmental Psychology. 1985; 21:1152- 1156.
Effects of estradiol benzoate on the pattern of eating and ethanol consumption.
Physiology and Behavior. 1982;29:61-65.
Changes in ethanol consumption during pregnancy of the rat.
Journal of Studies on Alcohol. 1982;43:137-145.
The effects of estradiol benzoate and MER-25 on ethanol consumption in the ovariectomized rat.
Journal of Comparative and Physiological Psychology. 1982;96:635-648.
Pharmacological analysis of analgesia and self- stimulation elicited by electrical stimulation of catecholamine nuclei in the rat brain.
Brain Research. 1978;152:529-542.
Analgesia produced by electrical stimulation of catecholamine nuclei in the rat brain.
Brain Research. 1977;123:369-372.
(B) Letters to the Editor
Gender identity stability and diagnosis in 5α-reductase deficiency.
Journal of Clinical Endocrinology and Metabolism. 2011; Published September 14.
From principles to process in disorders of sex development (DSD) care.
Horm Res Pædiatr. 2010;74(6):419–20.
Height and social adjustment: In reply.
Pediatrics. 2005;115:516- 517.
Sex determination, differentiation, and identity.
New England Journal of Medicine. 2004;350 (21):2204.
Quality of life and self-esteem in children treated for idiopathic short stature.
Journal of Pediatrics. 2003;143:691.
Psychosocial aspects of short stature and growth hormone therapy.
Journal of Pediatrics. 1999;135:133-134.
Adult height and psychological adaptation - authors’ response.
Journal of Clinical Endocrinology & Metabolism. 1998;83:4534.
(C) Editorial Commentaries for Growth, Genetics and Hormones
Treatment guidelines for children with disorders of sex development.
Growth, Genetics and Hormones. 2009;25(1):39-41.
Prevention of pediatric obesity: Meta-analysis of behavioral interventions.
Growth, Genetics and Hormones. 2009;25(1):21-22.
Pediatric obesity: Meta-analysis of non-surgical interventions.
Growth, Genetics and Hormones. 2009;25(1):19-21.
Disorders of Sex Development: Nomenclature. Letter to the Editor.
Growth, Genetics and Hormones. 2009;25(1):9-10.
Genital function and sensitivity following feminizing surgery.
Growth, Genetics and Hormones. 2008;24 (2):52-53.
Adult height of treated congenital adrenal hyperplasia patients.
Growth, Genetics and Hormones. 2008;24(2):38-40.
Gender of growth hormone recipients in the US and globally.
Growth, Genetics and Hormones. 2008;24(2):35-36.
Height and health-related quality of life. [e- abstract http://gghjournal.com/volume24/1/ab09.cfm].
Growth, Genetics and Hormones. 2008;24(1).
Dosing of growth hormone therapy according to IGF levels. [e-abstract http://gghjournal.com/volume24/1/ab01.cfm].
Growth, Genetics and Hormones. 2008;24(1).
Stature and status: height, ability, and labor market outcomes. [e-abstract http://www.gghjournal.com/volume23/2/ab21.cfm].
Growth, Genetics and Hormones. 2007;23(2).
Cognitive functions in children at risk of CAH treated prenatally with dexamethasone. [e-abstract http://www.gghjournal.com/volume23/2/ab18.cfm].
Growth, Genetics and Hormones. 2007;23(2).
Focusing illusion: wealth, height, and happiness.
Growth, Genetics and Hormones. 2007;23(2):27- 28.
Timing of menarche and the origins of conduct disorder. [e-abstract http://www.gghjournal.com/volume23/1/ab18.cfm].
Growth, Genetics and Hormones. 2007;23(1).
Growth attenuation in developmental disabilities. [e-abstract http://www.gghjournal.com/volume23/1/ab06.cfm].
Growth, Genetics and Hormones. 2007;23(1):12-13.
Transitioning children with chronic diseases to adult care. [e-abstract http://www.gghjournal.com/volume22/4/ab19.cfm].
Growth, Genetics and Hormones. 2006;22(4).
Consensus statement on management of intersex disorders. [e-abstract http://www.gghjournal.com/volume22/4/ab13.cfm].
Growth, Genetics and Hormones. 2006;22(4).
Autistic-like traits associated with elevated prenatal androgens. [e-abstract http://www.gghjournal.com/volume22/4/ab09.cfm].
Growth, Genetics and Hormones. 2006;22(4).
Quality of life and mental health in adolescents seeking bariatric surgery. [e-abstract http://www.gghjournal.com/volume22/3/ab17.cfm].
Growth, Genetics and Hormones. 2006;22(3).
Brain structure and cognitive deficits in Klinefelter’s syndrome. [e-abstract http://www.gghjournal.com/volume22/3/ab11.cfm].
Growth, Genetics and Hormones. 2006;22(3).
Brain function regulation by SRY. [e-abstract http://www.gghjournal.com/volume22/3/ab10.cfm].
Growth, Genetics and Hormones. 2006;22(3).
Idiopathic short stature: psychosocial development and GH treatment.
Growth, Genetics and Hormones. 2006;22(3):46-47.
Impaired cognitive function in congenital adrenal hyperplasia.
Growth, Genetics and Hormones. 2006;22(3):39-40.
Truth-telling and Turner syndrome: the importance of diagnostic disclosure. [e-abstract http://www.gghjournal.com/volume22/2/ab16.cfm].
Growth, Genetics and Hormones, 2006;22(2).
Effects of GH replacement in adult GH deficiency on patient-reported outcomes and cognitive function: a meta-analysis. [e-abstract http://www.gghjournal.com/volume22/2/ab10.cfm].
Growth, Genetics and Hormones. 2006; 22(2).
IGF-I and IQ in middle childhood.
Growth, Genetics and Hormones. 2005; 22(2):31- 32.
Efficacy of growth hormone during transition from adolescence to adulthood in patients with growth hormone deficiency.
Growth, Genetics and Hormones. 2006;22(1):14.
Motivations for GH/GnRHa treatment and psychosocial functioning.
Growth, Genetics and Hormones. 2006;22(1):12.
Adult height in Turner syndrome.
Growth, Genetics and Hormones. 2005;21(4):60- 61.
Aromatase inhibitor and growth in the pubertal male with GHD.
Genetics and Hormones. 2005;21 (4):57-58.
Compliance with medication recommendations.
Growth, Genetics and Hormones. 2005;21(4):54-55.
Quality of life in Turner syndrome after GH treatment. [e-abstract http://www.gghjournal.com/volume21/3/ab15.cfm].
Growth, Genetics and Hormones. 2005;21(3).
Neuropsychological sequelae and brain function in adults with childhood-onset GHD.
Growth, Genetics and Hormones. 2005;21(3):48.
Psychological benefits of growth hormone in children born small for gestational age. [e-abstract http://www.gghjournal.com/volume21/2/ab13.cfm].
Growth, Genetics and Hormones. 2005;21(2).
Sex differences in patients referred for evaluation of poor growth.
Growth, Genetics and Hormones. 2005;21(2):31.
Colsman M* Assessment of psychosocial aspects of short stature [Feature Article http://www.gghjournal.com/volume21/2/featureArticle.cfm].
Growth, Genetics and Hormones. 2005;21(2):18-25.
NICHD research planning workshop on intersex. [e -abstract www.gghjournal.com/volume21/1/ab14.cfm].
Growth, Genetics and Hormones. 2005;21(1).
Stature and psychosocial adjustment in adulthood.
Growth, Genetics and Hormones 2004;20(4):59- 60.
Ethics guidelines for intersex conditions.
Growth, Genetics and Hormones. 2004;20 (3):43.
Attitudes toward clinical management of intersexuality: The voices of 46,XY adult patients.
Growth, Genetics and Hormones. 2004;20(3):42.
Klinefelter syndrome: Phenotype and new research.
Growth, Genetics and Hormones. 2004;20 (2):31.
Sexual outlook for post-surgical ambiguous genitalia patients.
Growth, Genetics and Hormones. 2004;20(2):24.
Non-hormonal genetic influence on brain development.
Growth, Genetics and Hormones. 2004;20(1):14- 15.
Growth hormone effects on quality of life of young adults.
Growth, Genetics and Hormones. 2004;20(1):12- 13.
(D) Invited Articles/Commentaries
It’s not how short you are, but how you got there that counts.
Horm Res Pædiatr. 2011;75:146- 147.
Interpreting research results: the dangers of scientific jargon.
Cares Foundation Newsletter. 2006;5:8-9.
Growth hormone treatment for short stature: Inferences from FDA decisions and clinical practice.
Atrium. The Report of the Northwestern Medical Humanities and Bioethics Program. 2006;3:15-17. Available at: http://www.ama-assn.org/ama1/pub/upload/mm/384/cc2-short15623.pdf
Health-related quality of life as a primary endpoint for growth hormone therapy.
Hormone Research. 2006;65:250-252.
Treating short stature with growth hormones.
Virtual Mentor. Ethics Journal of the American Medical Association. 2005;11. Available at: http://www.ama-assn.org/ama1/pub/upload/mm/384/cc2- short15623.pdf
Hypospadias.
2003
Caring for the short, endocrinologically normal child.
Current Problems in Pediatrics. 1995;25:163- 170.
Projects
Disorders of Sex Development: A Survey of Clinical Practice
Disorders of Sex Development: Platform for Basic and Translational Research
Family Education for Confirmed Newborn Screen
Health-Related Quality of Life: A Pediatric Clinical and Research Tool